PDGFR (Platelet-derived advancement element receptors) are mobile area tyrosine kinase receptors for members of the platelet-derived growth aspect(PDGF) family. PDGF subunits -A and -B are crucial components regulating mobile proliferation, cellular differentiation, cell growth, advancement and many diseases which includes cancer. There are two forms of the PDGFR: PDGFR alpha and PDGFR beta. PDGFRA has been proven to interact with PDGFRB, PLCG1, Sodium-hydrogen antiporter three regulator one, Cbl gene, CRK, Caveolin 1 andPDGFC. PDGFRB has been proven to interact with PTPN11, NCK1, Grb2, Caveolin one, PDGFRA, Sodium-hydrogen antiporter 3 regulator one, RAS p21 protein activator 1, CRK, SHC1 and NCK2.
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